Cronin, S.J.F., Tejada, M.A., Song, R., Laval, K., Cikes, D., Ji, M., Brai, A., Stadlmann, J., Novatchikova, M., Perlot, T., Ali, O.H., Botta, L., Decker, T., Lazovic, J., Hagelkruys, A., Enquist, L., Rao, S., Koyuncu, O.O., Penninger, J.M. Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread. Cell bioRxiv [Preprint]. 2023 May 9:2023.05.09.539956. 

 
2022
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Van Crombrugge, E., Vanbeylen, E., Van Cleemput, J., Van den Broeck, W., Nauwynck, H./ Laval, K. (2022). Bacterial toxins from Staphylococcus aureus and Bordetella bronchiseptica predispose the horse’s respiratory tract to equine herpesvirus type 1 infection. Viruses 14(1), 149. doi.org/10.3390/v14010149.

 
2021
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Laval, K., and Enquist, L.W. (2021). The Potential Role of Herpes Simplex Virus Type 1 and Neuroinflammation in the Pathogenesis of Alzheimer's Disease. Front Neurol 12(458). doi: 10.3389/fneur.2021.658695.
Laval, K., Poelaert, K.C.K., Van Cleemput, J., Zhao, J., Vandekerckhove, A.P., Gryspeerdt, A.C., et al. (2021). The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1. Front Microbiol 12, 662686. doi: 10.3389/fmicb.2021.662686.
Van Cleemput, J., Koyuncu, O.O., Laval, K., Engel, E.A., and Enquist, L.W. (2021). CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing. J Virol 95(6). doi: 10.1128/jvi.02286-20.

 
2020
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Laval, K., and Enquist, L.W. (2020). The Neuropathic Itch Caused by Pseudorabies Virus. Pathogens 9(4). doi: 10.3390/pathogens9040254.
Laval, K., Maturana, C.J., and Enquist, L.W. (2020). Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses. J Vis Exp (160). doi: 10.3791/61121.
Van Cleemput, J., Poelaert, K.C.K., Laval, K., Vanderheijden, N., Dhaenens, M., Daled, S., et al. (2020). An Alphaherpesvirus Exploits Antimicrobial β-Defensins To Initiate Respiratory Tract Infection. J Virol 94(8). doi: 10.1128/jvi.01676-19.

 
2019
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Laval, K., Van Cleemput, J., Vernejoul, J.B., and Enquist, L.W. (2019). Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling. PLoS Pathog 15(11), e1008087. doi: 10.1371/journal.ppat.1008087.
Poelaert, K.C.K., Van Cleemput, J., Laval, K., Descamps, S., Favoreel, H.W., and Nauwynck, H.J. (2019a). Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses. Front Microbiol 10, 723. doi: 10.3389/fmicb.2019.00723.
Poelaert, K.C.K., Van Cleemput, J., Laval, K., Favoreel, H.W., Couck, L., Van den Broeck, W., et al. (2019b). Equine Herpesvirus 1 Bridles T Lymphocytes To Reach Its Target Organs. J Virol 93(7). doi: 10.1128/jvi.02098-18.
Poelaert, K.C.K., Van Cleemput, J., Laval, K., Xie, J., Favoreel, H.W., and Nauwynck, H.J. (2019). Equine herpesvirus 1 infection orchestrates the expression of chemokines in equine respiratory epithelial cells. J Gen Virol 100(11), 1567-1579. doi: 10.1099/jgv.0.001317.
Van Cleemput, J., Poelaert, K.C.K., Laval, K., Impens, F., Van den Broeck, W., Gevaert, K., et al. (2019a). Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection. Sci Rep 9(1), 4787. doi: 10.1038/s41598-019-41305-y.
Van Cleemput, J., Poelaert, K.C.K., Laval, K., and Nauwynck, H.J. (2019b). Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models. Vet Res 50(1), 13. doi: 10.1186/s13567-019-0630-6.
Van Cleemput, J., Poelaert, K.C.K., Laval, K., Van den Broeck, W., and Nauwynck, H.J. (2019). Deoxynivalenol, but not fumonisin B1, aflatoxin B1 or diesel exhaust particles disrupt integrity of the horse's respiratory epithelium and predispose it for equine herpesvirus type 1 infection. Vet Microbiol 234, 17-24. doi: 10.1016/j.vetmic.2019.05.009.

 
2018
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Laval, K., Vernejoul, J.B., Van Cleemput, J., Koyuncu, O.O., and Enquist, L.W. (2018). Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice. J Virol 92(24), e01614-01618. doi: 10.1128/JVI.01614-18.
Poelaert, K.C.K., Van Cleemput, J., Laval, K., Favoreel, H.W., Soboll Hussey, G., Maes, R.K., et al. (2018). Abortigenic but Not Neurotropic Equine Herpes Virus 1 Modulates the Interferon Antiviral Defense. Front Cell Infect Microbiol 8, 312. doi: 10.3389/fcimb.2018.00312.

 
2017
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Laval, K., Van Cleemput, J., Poelaert, K.C., Brown, I.K., and Nauwynck, H.J. (2017). Replication of neurovirulent equine herpesvirus type 1 (EHV-1) in CD172a(+) monocytic cells. Comp Immunol Microbiol Infect Dis 50, 58-62. doi: 10.1016/j.cimid.2016.11.006.
Van Cleemput, J., Poelaert, K.C.K., Laval, K., Maes, R., Hussey, G.S., Van den Broeck, W., et al. (2017). Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions. Sci Rep 7(1), 16656. doi: 10.1038/s41598-017-16804-5.
 

2016
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Laval, K., Favoreel, H.W., Van Cleemput, J., Poelaert, K.C.K., Brown, I.K., Verhasselt, B., et al. (2016). Entry of equid herpesvirus 1 into CD172a+ monocytic cells. J Gen Virol 97(3), 733-746. doi: 10.1099/jgv.0.000375.
Zhao, J., Negussie, H., Laval, K., Poelaert, K.C.K., and Nauwynck, H.J. (2016). Dual infections of equine herpesvirus 1 and equine arteritis virus in equine respiratory mucosa explants. Virus Res 220, 104-111. doi: 10.1016/j.virusres.2016.04.013.

 
 
 
2015
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Laval, K., Favoreel, H.W., Poelaert, K.C., Van Cleemput, J., and Nauwynck, H.J. (2015b). Equine Herpesvirus Type 1 Enhances Viral Replication in CD172a+ Monocytic Cells upon Adhesion to Endothelial Cells. J Virol 89(21), 10912-10923. doi: 10.1128/jvi.01589-15.
Laval, K., Favoreel, H.W., and Nauwynck, H.J. (2015a). Equine herpesvirus type 1 replication is delayed in CD172a+ monocytic cells and controlled by histone deacetylases. J Gen Virol 96(Pt 1), 118-130. doi: 10.1099/vir.0.067363-0.
Grauwet, K., Vitale, M., De Pelsmaeker, S., Jacob, T., Laval, K., Moretta, L., et al. (2015). Pseudorabies virus US3 protein kinase protects infected cells from NK cell-mediated lysis via increased binding of the inhibitory NK cell receptor CD300a. J Virol. doi: 10.1128/jvi.02902-15.

 
2014
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Baghi, H.B., Laval, K., Favoreel, H., and Nauwynck, H.J. (2014). Isolation and characterization of equine nasal mucosal CD172a + cells. Vet Immunol Immunopathol 157(3-4), 155-163. doi: 10.1016/j.vetimm.2013.12.001.

 
2012
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Doceul, V., Hollinshead, M., Breiman, A., Laval, K., and Smith, G.L. (2012). Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions. J Gen Virol 93(Pt 9), 1876-1886. doi: 10.1099/vir.0.043943-0.